中文摘要：

为研究多孔载药微球中活性物的释放机理及控释性能，以难溶性Parsol 1789为模型药物，结合扩散的连续性方程和溶解理论，建立了此类药物从多孔聚合物微球载体中释放的溶解-扩散模型，并利用数值求解得到不同时刻活性物累积释放量的模型方程。用溶解度不同的活性物释放数据对方程进行拟合并求得各组分在多孔聚合物基质中的有效扩散系数和溶解速率常数。结果表明：不同的制备条件和组成对扩散系数有重要影响，而溶解速率常数主要由活性物性质决定。

英文摘要：

In order to study the release mechanism and control release performance of porous micro spheres, the Parsol 1789 was chosen as the model hydrophobic ingredient, by taking consideration of diffusion equation and dissolution theory. A new dissolution-diffusion model was developed for description the cumulative release amount in different time. The model was used to fit the release profiles of three actives with different solubility, and the diffusion coefficient and dissolution rate constant were obtained. The results show that different preparation methods and compositions have important influence on diffusion coefficient, whereas the dissolution rate constant is decided mainly by the actives properties.