东篱科研大数据发现系统（DRDS）

位置：成果数据库 > 期刊 > 期刊详情页

1000名中国正常成人杏仁核体积高分辨力MRI测量

ISSN号：1003-3289
期刊名称：《中国医学影像技术》
时间：0
分类：R322.81[医药卫生—人体解剖和组织胚胎学;医药卫生—基础医学] R445.2[医药卫生—影像医学与核医学;医药卫生—诊断学;医药卫生—临床医学]
作者机构：[1]首都医科大学宣武医院放射科,北京100053, [2]中国科学院生物物理研究所脑与认知科学国家重点实验室,北京100101
相关基金：国家863计划项目（2006AA02z391）; 国家973计划项目（2005CB522800、2004CB318101）; 国家自然科学基金（30621004）

作者：潘克校[1], 陈楠[1], 王星[1], 李坤成[1], 卓彦[2], 陈霖[2]

关键词：杏仁核, 磁共振成像, 人体测量, Amygdala, Magnetic resonance imaging, Anthropometry

中文摘要：

目的基于高分辨力MRI测量中国汉族正常成人杏仁核体积,探讨杏仁核体积与年龄、性别的关系。方法采用全国15家医院多中心临床研究形式,选取1000名中国健康成年受检者,按年龄分为5组：18～30岁（第1组）、31～40岁（第2组）、41～50岁（第3组）、51～60岁（第4组）及61岁以上（第5组）,行大脑三维磁化强度预备梯度回波序列T1WI,应用三维体积分析软件测量杏仁核体积。采用方差分析比较不同年龄组杏仁核体积,t检验比较不同性别、侧别杏仁核体积。结果①杏仁核体积在总体样本及各组内男、女性间差异均有统计学意义（P均〈0.05）,男性大于女性。②总体样本左、右杏仁核体积差异有统计学意义（P〈0.001）,左侧高于右侧。③第1组、第2组及总体样本左侧杏仁核体积男性大于女性,第1组、第2组、第3组、第5组及总体样本右侧杏仁核体积男性大于女性,差异有统计学意义。④男性双侧杏仁核体积组间比较：第1组与第3～5组、第2组与第3～5组、第3组与第5组、第4组与第5组间差异均有统计学意义;女性：第1～4组与第5组间差异均有统计学意义。结论高分辨力MRI能够清晰显示杏仁核形态,用于准确测量杏仁核体积,为建立中国汉族标准脑提供科学数据。

英文摘要：

Objective To measure the amygdala volumes of normal Chinese Han nationality adults based on high-resolution MRI, and to explore correlation of amygdala volume with the age and sex. Methods Totally 1000 normal Chinese Han nationality adults ranging from 18 to 78 years were selected from 15 hospitals, which were divided into 5 groups according to age： 18—30 years old （group 1）, 31—40 years old （group 2）, 41—50 years old （group 3）, 51—60 years old （group 4）, ≥61 years old （group 5）. All subjects underwent brain MR scan with T1W 3D magnetization prepared gradient echo sequence. The amygdala volume were measured with 3D analysis software. The amygdala volume were compared with age and sex by ANOVA and t-test. Results Amygdala volume of male was larger than that of female in total samples and every group （all P0.05）. Left amygdala volume was larger than that of right in total samples （P0.001）. Left amygdala volume of male was larger than that of female in total samples in group 1 and group 2; right amygdala volume of male was larger than that of female in total samples, group 1, group 2, group 3 and group 5. Statistical differences were found in male bilateral amygdala volume between each two groups except group 1 and group 2, group 3 and group 4. Statistical differences were found in female bilateral amygdala volume between group 5 and other groups. Conclusion Amygdala can be displayed clearly and measured accurately with high-resolution MRI. Normal reference values of amygdala are provided for the Chinese normal standards brain database.

同期刊论文项目