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中文摘要：
核因子κB抑制蛋白（inhibitor of NF—κB，IκB）是核因子κB（nuclear factor-kappa B，NF—κB）的抑制因子。IκB蛋白家族与Rel／NF—κB蛋白家族一样，也是一个大家族，它们都来源于相同祖先NF—κB／IκB超家族的Rel同源区-锚蛋白重复序列区（Rel homology domain-ankyrin repeat domain，RHD-ARD）结构。IκB蛋白一方面可以在胞浆中与NF—κB二聚体结合形成复合物，抑制NF—κB进入细胞核发挥转录激活作用；另一方面也可以直接在细胞核内抑制NF—κB与DNA的结合。
英文摘要：
IκB is an inhibitor of nuclear factor - kappa B （ NF -κB） and presents in the majority of cells. Eight structurally related members of the mammalian IκB family have been described ： IκBet, IκBα, IκBβ, Bcl - 3, IκBγ, IκBδ, p100 and p105. The ankyrin repeat domain of IκB can interact with NF -κB, and sequester NF -κB in the cytoplasm as inactive complexes. Most recently, IκBα has been found to inhibit p53 tumor suppressor protein by binding p53 to form a cytoplasmic p53 · IκBα complex and studies have shown that p1000 profoundly sensitizes cells to death - receptor - mediated apoptosis. The current review is to describe the members of IκB family, their related signaling pathways, and their application in tumor therapy.
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