中文摘要：

C型凝集素（C-type lectin）代表一个识别碳水化合物配体依赖于钙离子（Ca2＋）参与的糖原结合蛋白家族,含有一个或多个一级结构和二级结构同源的碳水化合物识别结构域。随着研究的深入,越来越多的C型凝集素能够识别体内的非糖类的配体,包括蛋白质和脂类等。这些C型凝集素在维持机体稳态、免疫防御以及免疫监视等重要生理病理过程中发挥着重要作用。就C型凝集素的结构、分类和在免疫系统中的功能作一介绍。

英文摘要：

C-type lectins are Ca2＋-dependent glycan-binding proteins and share primary and secondary structural homology in their carbohydrate-recognition domains（CRDs）.However,many members of this family are recently identified not to bind carbohydrates and have evolved to recognize non-sugar ligands such as proteins and lipids.The large family of C-type lectins has an important role in the physiological functions and pathological processes including immune homeostasis,immune defenses,and immune surveillance and so on.In this short review,we summarize the structure of C-type lectin domain,the classification of C-type lectins and their role in the immune system.