随着近年腰椎间盘突出症发病率逐渐升高,腰椎间盘突出的动物模型引起众多学者及医务工作者的重视和深入研究。建立与人类相关性、可比性较强的腰椎间盘突出的动物模型有利于了解和掌握疾病的发生、发展及相关的有效治疗方法,具有现实的临床意义。文章通过对近10年国外有关腰椎间盘突出动物模型的动物选择、研究方法和模型应用等方面进行总结比较分析,综述了腰椎间盘突出动物模型的研究现状和进展,并对其存在问题和应用前景进行了展望。
With the increase of incidence of lumbar disc herniation year by year,the scholars and the medical workers paid more attention to the animal models of lumbar disc herniation.Establishment of lumbar disc herniation models,which had strong relativity and comparability to human,could avail to understand and master the happening and development of the disease,related effective treatment methods,with the clinical significance of reality.The article summarized animal selection,research method and model application of recent 10 years abroad,reviewed research situation and progress of animal model of lumbar disc herniation,and prospected its problems and application outlook.