中文摘要：

季全碳中心的构筑一直是有机合成中的难点和热点,其中以廉价三级溴代烷为原料,通过分子间C（sp-3）—C（sp-3）键形成来合成该类季全碳中心更是鲜有报道.采用廉价锌粉作为还原性自由基引发剂,诱导三级溴代烷形成叔碳自由基,进而实现用烯烃捕获该自由基的策略来高效构筑C（sp-3）—C（sp-3）键季全碳中心.

英文摘要：

The construction of the quaternary carbon center has been a difficult and hot issue in organic synthesis. In particular, the synthesis of quaternary carbon center by the formation of the intermolecular C （sp3）-C（sp3） bond with cheap tert-alkyl bromides is rarely reported. Recently, our group reported that nickel-catalyzed reductive coupling of aryl bromides with tertiary alkyl halides. Based on this, we proposed that using cheap reductive metal as a free radical initiator, mediated the formation of tertiary carbon free radicals from tert-alkyl bromides, and then the free radical captured by olefin to build C（sp3）-C（sp3） bond quaternary carbon center efficiently. Herein, we report the application of this strategy in constructing quaternary carbon center by Zn powder mediated reductive coupling reaction.