中文摘要：

三阴性乳腺癌（TNBC）是乳腺癌的一种特殊亚型，对内分泌治疗无效，针对Her-2靶点的靶向治疗如赫赛汀、拉帕替尼等也并不适用。目前，常规化疗是内科治疗TNBC的惟一途径。寻找TNBC的治疗靶点是目前乳腺癌的研究热点之一，正在研发的新靶向治疗药物包括PARP-1抑制剂、EGFR抑制剂、CXCR4抑制剂、抗血管生成、Src酪氨酸激酶抑制剂、mTOR抑制剂等。

英文摘要：

Triple-negative breast cancer （TNBC） is a special subtype of breast cancer which is invalid to endocrine therapy. Anti-Her2 targeted therapies such as herceptin and lapatinib are not suitable to TNBC. At present, conventional chemotherapy is the only way for the medical therapy of TNBC. Thus, searching for novel therapeutic agents for TNBC is one of hot researches of breast cancer. New targeted therapy drugs such as PARP-1 inhibitors, EGFR inhibitors, CXCR4 inhibitors, anti-angiogenesis drugs, Src tyrosine kinase inhibitor, and mTOR inhibitor are being researched.