中文摘要：

背景铝在人体内的蓄积给维持血液透析患者带来了严重危害,然而目前国内对血液透析患者血清铝水平的大规模调查尚不多见。目的检测福建省慢性肾衰竭维持血液透析患者血清铝水平,探讨影响血清铝水平的因素。方法收集2012年1月—2013年12月福建省厦门市、漳州市、龙岩市、泉州市、三明市15所医院透析中心慢性肾衰竭维持血液透析患者和健康体检者血清标本,共收集慢性肾衰竭维持血液透析患者449例,健康体检者262例,采用AA800原子吸收光谱仪检测血清中铝水平。采用多重线性回归分析影响慢性肾衰竭患者血清铝水平的因素。结果慢性肾衰竭维持血液透析患者血清铝水平为（18.34±6.16）μg/L,高于健康对照者的（1.57±0.45）μg/L（t=2.324,P〈0.05）。52例（11.6%）慢性肾衰竭维持血液透析患者血清铝水平超过了国际肾脏病组织推荐的慢性肾衰竭患者血清铝允许上限值（30μg/L）。男性慢性肾衰竭维持血液透析患者血清铝水平为（18.45±6.48）μg/L,女性为（18.22±5.64）μg/L,两者比较,差异无统计学意义（t=1.058,P〉0.05）。各透析中心透析液及所在城市饮用水铝水平比较,差异有统计学意义（F=4.252、3.316,P〈0.05）。服用磷结合剂、Vit D制剂、注射促红细胞生成素（EPO）及近期接受输血治疗的血液透析患者血清铝水平高于未接受上述治疗患者（P〈0.05）。慢性肾衰竭维持血液透析患者中不同饮茶量、食加工面食比例者血清铝水平比较,差异有统计学意义（P〈0.05）;不同食肉食比例患者血清铝水平比较,差异无统计学意义（P〉0.05）。多重线性回归结果显示,饮茶量、面食饮食、饮用水铝含量、每日尿量、透析频率、透析液铝含量、服用磷结合剂、服用Vit D、注射EPO、输血为影响慢性肾衰竭患者血清铝水平的因素（P〈0.05）。结论福建省慢性肾衰竭维持血液透析?

英文摘要：

Background Aluminium accumulation can bring severe damages to maintenance hemodialysis patients.However there is little large- scale clinical investigation on it. Objective To detect the serum aluminum level in patients with chronic renal failure maintaining hemodialysis in Fujian Province and to explore possible influencing factors for serum aluminum level. Methods Serum samples of 449 chronic hemodialysis patients and 262 normal controls were collected from the samples of patients with chronic renal failure maintaining hemodialysis and healthy persons in the hemodialysis centers of 15 hospitals in Xiamen,Zhangzhou,Longyan,Quanzhou and Sanming from January 2012 to December 2013,whose aluminum concentration in the serum was detected by AA800 graphite furnace atomic absorption spectrometer. Possible relationship of serum aluminum concentration with multiple factors was tested by multivariate linear regression analysis. Results The average serum aluminumconcentration of hemodialysis patients in Fujian Province was（ 18. 34 ± 6. 16） μg / L,which was significantly higher than that of normal controls（ 1. 57 ± 0. 45） μg / L（ t = 2. 324, P 0. 05）. 52 patients（ 11. 6%） exceeded the upper limit value recommended by the international renal diseases organization（ 30 μg / L）. The serum aluminum concentration was（ 18. 45 ±6. 48） μg / L in males and（ 18. 22 ± 5. 64） μg / L in females without significant difference（ t = 1. 058, P 0. 05）. The differences of dialysate from each center and aluminium level of drinking water from each city were significant（ F = 4. 252,3. 316,P 0. 05）. The aluminum concentration in patients who took conjugation agent of phosphorus and Vitamin D,administered erythropoietin（ EPO）,received treatment of blood transfusion recently was higher than that otherwise（ P 0. 05）.The differences of serum aluminum concentration were significant in consumption of tea and processed flour products proportion（ P 0. 05） but not in the proportion of meat diet（ P 0