中文摘要：

目的：对消癌平联合CPT-11化疗治疗老年晚期胃癌的临床疗效和安全性进行观察。方法：选取2013年3月至2015年3月在我院接受治疗的120例老年晚期胃癌患者,随机分为观察组和对照组,每组各60例。两组患者均采用伊立替康（CPT-11）化疗方案,而观察组在此基础上给予消癌平注射液进行抗肿瘤中药治疗,连用14d为一个周期,两组患者均持续治疗4个周期。观察比较两组患者的肿瘤标志物水平、近期疗效、远期疗效及不良反应发生率。结果：经过化疗后两组患者的血清癌胚抗原（CEA）、糖类抗原199（CA199）和糖类抗原242（CA242）水平均显著低于治疗前（P〈0.05）;观察组治疗后的CEA、CA199和CA242水平显著低于对照组（P〈0.05）。观察组的疾病控制率（disease control rate,DCR）为85.0%,显著高于对照组61.7%（P〈0.01）。观察组PFS平均PFS（11.57±2.09）个月显著长于单药组（9.31±0.62）个月（P〈0.05）。观察组化疗期间的白细胞减少、谷丙转氨酶升高、腹泻、口腔黏膜炎和手足综合征发生率显著低于单药组（P〈0.05）。结论：消癌平注射液联合伊立替康化疗治疗晚期胃癌效果明显,不良反应发生率低,在临床上值得推广应用。

英文摘要：

Objective： To observe the efficacy and security of Xiaoaiping injection combined with CPT-11 chemotherapy for elderly patients with advanced gastric cancer. Method： 120 patients with advanced gas-tric cancer in our hospital from March 2013 to March 2015 were randomly divided into observation group and control group,60 cases in each group. Both groups received irinotecan（ CPT- 11） chemotherapy regimens,while based on the above treatment the observation group was given the additional treatment of Xiaoaiping injection of anti- tumor traditional Chinese medicine. Both groups were treated for four consecutive treatment cycles and each cycle contained 14 days. The tumor markers,short- term effect,long- term efficacy and incidence of adverse reactions were compared in the two groups. Result： The CEA,CA199 and CA242 levels in both groups were significantly lower after treatment（ P〈 0. 05）. The CEA,CA199 and CA242 levels in the observation group after treatment were significantly lower than those in the control group（ P〈 0. 05）.The DCR of the observation group was 85. 0%,which was significantly higher than that of the control group（ P 0. 01）. The mean PFS of the observation group was（ 11. 57 ± 2. 09） months,which was significantly longer than that of control group（ P〈 0. 05）. The levels of leukopenia,increased alanine aminotransferase,diarrhea,stomatitis and hand- foot syndrome in the observation group were significantly lower than those in the monotherapy group（ P〈 0. 05）. Conclusion： Xiaoaiping injection combined with irinotecan chemotherapy for the treatment of advanced gastric cancer has an obvious effect and a low incidence of adverse reactions,which is worthy of clinical application.