中文摘要：

目的：观察血小板源性生长因子（PDGF）-BB对乳腺癌SK-BR-3细胞迁移、增殖的促进作用。方法分别以0．5、1、2、4ng/mL质量浓度的PDGF-BB干预对数期SK-BR-3乳腺癌细胞，细胞计数法和內盐法（MTS）检测细胞增殖情况，细胞迁移试验检测细胞迁移能力。结果与未加入任何药物的SK-BR-3乳腺癌细胞相比，4ng/mL的PDGF-BB对SK-BR-3乳腺癌细胞的迁移及增殖有明显促进作用，该促进作用与药物质量浓度呈正相关。结论在一定质量浓度范围内，PDGF-BB能明显促进人源性SK-BR-3细胞的迁移和增殖。

英文摘要：

Objective To explore the effects of platelet-derived growth factor （ PDGF）-BB on the migration and prolif-eration of SK-BR-3 mammary carcinoma cells .Methods SK-BR-3 mammary carcinoma cells in logarithm growth stage were treated with different concentrations of PDGF-BB （0.5, 1, 2, 4 ng/mL）.The proliferation was determined by cytom-etry and MTS assay , and the migration ability was detected by cell migration assay .Results Compared with SK-BR-3 mammary carcinoma cells without any drug , 4 ng/mL PDGF-BB promoted the migration and proliferation of SK-BR-3 mam-mary cells and it was positively associated with the drug concentration .Conclusions The PDGF-BB can promote the mi-gration and proliferation of human SK-BR-3 cells in a specific concentration range .