中文摘要：

toll样受体（toll-like receptors,TLRs）是新近十余年发现的主要在哺乳动物细胞表面进化上高度保守的受体分子家族,主要通过识别病原相关分子模式（pathogen-associated molecular patterns,PAMPs）来迅速激活天然免疫系统,并且还能够诱导获得性免疫的产生。迄今为止,已经发现哺乳动物至少有13种toll样受体,其中人的toll样受体鉴定出11种（TLR1-TLR11）。在某些肿瘤中TLRs的表达发生量的变化,并且许多微生物组分和药物能够通过TLRs信号通路介导肿瘤的免疫治疗。

英文摘要：

Toll like receptors （TLRs）, a pattern conservative receptor superfamily that recognizes distinct pathogen -associated molecular patterns ,which can lead not only to the responses of the innate immunity but also to the development of the antigen -specific adaptive immunity, by now,we have found 13 TLRs in mammals, of the total human have 11 TLRs （TLR1 -TLR11 ）, the express of TLRs have changed in some carcinomas, and microorganism compositions and drugs mediated the tumor immunotherapy by the way of TLRs signal transduetion.