中文摘要：

肿瘤坏死因子受体相关因子（TRAF）是一类胞内接头蛋白,最先发现时它是作为TNF-R超家族的下游信号通路中的一员,后来发现TRAF是TNFR和TLR、NLR等家族的信号传导通路中重要的信号传导因子,调节MAPK等信号通路的激活,具有影响细胞的增殖、存活、凋亡、参与炎性反应、免疫应答等多种功能,是细胞内重要的信号传导蛋白。TRAF家族中每一个蛋白都有独特的作用,研究发现TRAFs在正常及异常组织中的表达不同,进一步发现TRAF在不同疾病的发生发展中起到不同的调控作用,目前对于它们之间的相互作用和联系的研究越来越深入,为寻找治疗TRAF参与疾病的方法提供新的理论基础。

英文摘要：

Tumor necrosis factor receptor-associated factor （TRAF） proteins are cytoplasmic adapter proteins, which are originally identified as signaling adaptors that bind directly to the cytoplasmic regions of receptors of the TNF-R superfamily. TRAFs have emerged as the major signal transducers for the TNF receptor superfamily, the Toll-like re- ceptor （TLR） superfamily and NOD-like receptor （NLR） superfamily, and have been demonstrated to mediate activation of mitogen-activated protein kinases （MAPK）. Also TRAFs are important cytoplasmic adapter proteins that have diverse and widespread physiological functions, including proliferation, cell survival, apoptosis, inflammation and immune sys- tem regulation. The members of TRAFs have different function, some studies have demonstrated that TRAFs express differently in normal and abnormal tissues, and it has different regulating function in the occurrence and development of different diseases. Nowadays, more and more researches on the interaction and association between them have pro- vided a new theoretical basis for treating TRAF-related disease.