中文摘要：

芳香烃受体（aryl hydrocarbon receptor，AhR）是药物及毒物代谢酶的一种重要转录调控因子，主要调控细胞色素P-450酶系家族I（CYPl）和一些Ⅱ相代谢酶的表达，还具有许多内源性功能，包括调控细胞周期、免疫应答和细胞分化。AhR还与化学致癌有关。内源性配体持续激活AhR是细胞发挥正常生理功能的必要条件之一；但外源性配体激活AhR则对机体有害。该文对近年来AhR的内外源性配体研究进展进行综述，主要介绍内外源性配体的类型、结构和功能等以及一些新配体的特征。

英文摘要：

Aryl hydrocarbon receptor （AhR） is an important transcriptional regulator of drug or toxic metabolizing enzymes that dominantly controls the expression of CYP1 family genes and some phase Ⅱ enzymes. AhR also has many endogenous functions including cell cycle control, immune response, and cell differentiation. In addition, AhR is well-known to be involved in chemically induced carcinogenesis. While exogenous activation of AhR has adverse effects on human organism, sustained activation of AhR by endogenous ligands is indispensable for proper cell functions. In this paper, an overview of the recent studies about endogenous and exogenous ligands of aryl hydrocarbon receptor was presented, which introduced their types, structures, functions and characteristics of some new ligands.