中文摘要：

目的：探究中晚期宫颈鳞癌放化疗后复发未控的危险因素,为改善治疗效果提出理论依据.方法：选取我院2008年10月至2011年10月收治的127例行放化疗治疗的中晚期宫颈鳞癌患者进行回顾分析,按照其是否出现复发未控分为观察组及对照组,对比两组患者一般资料,并将存在统计学意义的指标纳入Logistic多因素回归分析.结果：127例行放化疗治疗的中晚期宫颈鳞癌患者中,29例出现复发未控,复发未控率为22.8％;单因素分析发现,其肿瘤分化程度、癌灶直径、转移情况、治疗前血红蛋白、化疗时间及放疗时间指标存在统计学差异;多因素回归分析发现,肿瘤低分化、癌灶直径≥4 cm、肿瘤淋巴结转移、治疗前血红蛋白≤90g/L、化疗时间＜3疗程及放疗时间＞8周是影响中晚期宫颈癌患者放化疗后复发未控的独立危险因素（P＜0.05）.结论：肿瘤低分化、癌灶直径≥4cm、肿瘤淋巴结转移、治疗前血红蛋白≤90 g/L、化疗时间＜3疗程及放疗时间＞8周是影响中晚期宫颈癌患者放化疗后复发未控的独立危险因素,应按照患者实际情况,制定相应个体化治疗方案,以达到最佳疗效,降低复发未控发生率.

英文摘要：

Objectives： To explore the risk factors of relapse of cervical squamous carcinoma after radiotherapy and chemotherapy and put forward the theoretic basis for improving the treatment effect. Method： We made a retrospective analysis of the patients in middle and late stage of cervical squamous cell carcinoma who received radiotherapy and chemotherapy in our hospital from October 2008 to October 2011. 127 cases were divided into the observation group and the control group. We com- pared their general information and included those statistical significant indicators into Logistic regression analysis. Results： There were 29 （22.8%） cases of uncontrolled relapse among 127 cases. Univariate analysis showed that the degree of tumor differentiation, tumor diameter, metastasis, hemoglobin level before treatment, chemotherapy and radiation time existed signifi- cant difference ; multivariate regression analysis showed that poorly differentiated tumors, tumor diameter ≥ 4 cm, lymph node metastasis, pre - treatment hemoglobin ≤90g/L, chemotherapy time 〈 3 course of treatment and radiotherapy time 〉 8 weeks were independent risk factors（ P 〈 0. 05 ）. Conclusion： Poorly differentiated tumors, tumor diameter ≥4cm, lymph node metastasis, pre- treatment hemoglobin ≤90g/L, chemotherapy time 〈 3 course of treatment and radiotherapy time 〉 8 weeks were independent risk factors. Health care providers should develop appropriate individualized treatment pattern according to patients＇ situations.