大电导钙激活钾通道(large conductance Ca2+-activated K+channels,BKCa),是细胞膜上一类重要的离子通道,广泛表达于包括心血管系统在内的机体各部分,在调节心血管活动中发挥重要作用。本文就近年来心血管BKCa通道的研究进展,包括其结构特征、功能及其调控作一简要综述。
The large conductance Ca2 +-activated potassium channels(BKCa channels),an important class of ion channels in cell membrane,are widely expressed in each part of the body including cardiovascular system,and play an important role in regulating cardiovascular activity.This review introduces the recent progress on the structural features,function,and modulation of BKCa channels in cardiovascular system briefly.