目的:研究毛茛科植物黄连Coptis chinensis的化学成分。方法:利用柱色谱、凝胶柱色谱、高效液相色谱等各种色谱技术对黄连的95%进行分离,根据其所得化合物的理化性质与UV,IR,MS,NMR等光谱数据鉴定其结构。结果:从黄连的95%乙醇提取物的氯仿萃取部分分离得到7个已知成分,分别鉴定为香草酸(1),落叶松树脂醇(2),原儿茶酸乙酯(3),小檗碱(4),丹参素甲酯(5),反式阿魏酰基酪胺(6),氧化小檗碱(7)。结论:其中,化合物(3),(5),(6)为首次从该属植物中分离得到。
Objective:Aim To study the chemical constituents of Co.chinensis Franch.Method: The compounds were separated and purified by column chromatography and their structures were established by spectroscopic methods.Result: Seven compounds were isolated from the chloroform extract of C.chinensis Franch,whose structures were determined as(1),vanillic acid(1),lariciresinol(2),protocatechuic acid ethyl ester(3),berberine(4),3,4,α-trihydroxy-methyl phenylpropionate(5),N-tran-feruloyltyramine(6),Oxyberberine(7).Conclusion: Compounds 3,5,6were isolated from this genus for the first time.