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（±）-迷迭香酸（Rosmarinic acid）的全合成
  • ISSN号：0567-7351
  • 期刊名称：《化学学报》
  • 时间：0
  • 分类：O629.9[理学—有机化学;理学—化学]
  • 作者机构：[1]华东理工大学药学院,上海200237, [2]第二军医大学药学院,上海200433
  • 相关基金：长江学者创新团队计划（No.30725045）; 国家863计划（No.2006AA02Z338）资助项目 感谢复旦大学化学系王全瑞教授在机理解释部分给予的指导.
作者： 袁虎[1], 单磊[2], 孙青龑[2], 韩伟[1]
关键词： 藜芦醛, 脱甲基, 全合成, (±)-迷迭香酸, vertraldethyde, demethylation, total synthesis, （±）-rosmarinic acid
中文摘要：

以藜芦醛为起始原料,经Erlenmeyer反应、水解开环、还原、羧基保护、酯化缩合、Kunz-Waldmann转化、脱甲基7步反应,完成了（±）-迷迭香酸（Rosmarinic acid）的全合成,并重点对甲醚化迷迭香酸脱甲醚方法进行了研究,探索出一条原料便宜易得、高收率的（±）-迷迭香酸合成路线.

英文摘要：

（±）-Rosmarinic acid was synthesized from vertraldethyde by the reaction of Erlenmeyer,hy-drolytic loop-open,reduction,carboxyl protection,esterification,Kunz-Waldmann procedure and demethy-lation.The methods of demethylation of methylated Rosmarinic acid were studied.An efficient synthetic route of（±）-rosmarinic acid with cheap materials was obtained.

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期刊信息
  • 《化学学报》
  • 北大核心期刊（2014版）
  • 主管单位:中国科学院
  • 主办单位:中国化学会 中国科学院上海有机化学研究所
  • 主编：周其林
  • 地址：上海市零陵路345号
  • 邮编：200032
  • 邮箱：hxxb@sioc.ac.cn
  • 电话：021-54925085
  • 国际标准刊号：ISSN：0567-7351
  • 国内统一刊号：ISSN：31-1320/O6
  • 邮发代号:4-209
  • 获奖情况:
  • 首届国家期刊奖,第二届国家期刊奖提名奖,中国期刊方阵“双高期刊”
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  • 被引量:28694