中文摘要：

目的：研究白术总提取物和二个不同部位（100％乙醇和50％乙醇部位）对大鼠调血脂和保肝的作用，并确定白术的有效部位。方法：采用高脂模型-预防性给受试物法，给予大鼠白术3种不同提取流份灌胃4周，测定体重和血清中胆固醇（TC）、甘油三酯（TG）和高密度脂蛋白（HDL-C）的含量以及谷丙转氨酶（ALT）和谷草转氨酶fAST）的活性，并观察肝脏病理切片。结果：白术总提取物和100%乙醇部位能显著降低小鼠体重值和TC、TG、动脉硬化指数（AI）水平（P〈0．01）。白术总提取物和100％乙醇部位都具有升高高脂血症大鼠血清中HDL-C水平（P〈0．05或P〈0．01）的作用，但只有100％乙醇部位降低LDL-C（P〈0．01）。白术总提取物，100％乙醇和50％乙醇部位都能拮抗ALT、AST活性的升高（P〈0．01），并且白术总提物组和100％乙醇部位组高脂血症大鼠的肝系数得到了显著性改善（P〈0．05）。结论：白术中亲脂性天然产物（100％乙醇部位）具有较强的降血脂作用，白术总提取物和亲脂性天然产物（100％乙醇部位）都有一定的保肝作用。

英文摘要：

Objective. To investigate preventive effects of Atractylodes macrocephala Koidz Decoction （AKD）and its two fractions （100% alcohol and 50% aqueous alcohol） on the levels of plasma lipid and liverin rat, and define the. bioactive fraction of AKD. Methods： The experiment used the model of metabolic disturbance of lipid-preventive tested sample. The rats were divided into six groups： control, high fat diet （HFD）, positive HFD control, water extract from AKD treatment, 100% ethanol fraction treatment and 50% ethanol fraction treatment. Serum levels of TC, TG and HDL-C were measured. Also, activities of ALT and AST were determined. Results： Compared with HFD control group, AKD and itsl00% ethanol fraction significantly reduced TC, TG, AST, ALT and the arteriosclerosis Index （AI） （P〈0.01）. AKD and its 100% fraction increased the levels of serum HDL-C （P〈0. 05 or P〈0. 01）, but only 100% fraction reduced level of serum LDL-C （P〈0. 01）. All AKD and its two fractions could suppressed the increase of ALT, ASTs activities （P~0. 05）, and AKD and its 100% fraction improved the ratio of liver and body weigh （P〈0.05）. Conclusion： Non-polar natural products （100% ethanol fraction） from AKD showed significant effect on the regulation of serum lipid levels, and both AKD and its non-polar.natural products （100% ethanol fraction） protected the liver in hyperlipidemic rats.