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Phenotypic and Functional Analysis of LCMV gp33-41-Specific CD8 T Cells Elicited by Multiple Peptide Immunization in Mice Revealed the Up-regulation of PD-1 Expression on Antigen- Specific CD8 T Cells

ISSN号：1672-7681
期刊名称：《中国免疫学杂志：英文版》
时间：0
分类：R329.2[医药卫生—人体解剖和组织胚胎学;医药卫生—基础医学]
作者机构：[1]Institute of Dermatology, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Nanjing 210042, China, [2]Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China, [3]Institute of Bioengineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China
相关基金：This work was supported by the grants from the National Natural Science Foundation of China （No.30672474, No.30572199, No.30230350, and No.30371651） and grants from Institute of Dermatology, Chinese Academy of Medical Sciences ＆ Peking Union Medical College.

作者： Yi Liu[1,2], Lihui Xu[3], Yiqun Jiang[1], Jianfang Sun[1], Xianhui He[2]

关键词： LCMV, T细胞, 肽疫苗, 表型, LCMV, CD8 T cell, peptide vaccine, phenotype, PD-1

中文摘要：

抗原特定的 CD8 T 房间的显型和功能仔细与治疗学的种痘的功效被联系。这里，我们证明有在 Freund 的助手的 LCMV gp33-41 肽(KAV ) 的多重免疫能与 CD127 和 CD62L 分子的低表示导致 KAV 特定的 CD8 T 房间。禁止的受体 PD-1 也在怒气和淋巴节点在 KAV 特定的 CD8 T 房间上在 KAV 特定的 CD8 T 房间，和它的表示水平的实质的部分上被表示高得多什么时候与那些相比在外部血。而且， KAV 特定的 CD8 T 房间能明确地在 vivo 杀死搏动 KAV 的目标房间，但是效率是低的。这些数据建议有在 Freund 的助手的肽的那张主要增加的种痘时间表能与部分功能的疲劳得到像受动器的显型的抗原特定的 CD8 T 房间，它可以仅仅对病原体提供短期的保护。

英文摘要：

The phenotype and function of antigen-specific CD8 T cells are closely associated with the efficacy of a therapeutic vaccination. Here we showed that multiple immunizations with LCMV gp33-41 peptide （KAV） in Freund＇s adjuvant could induce KAV-specific CD8 T cells with low expression of CD127 and CD62L molecules. The inhibitory receptor PD-1 was also expressed on a substantial part of KAV-specific CD8 T cells, and its expression level on KAV-specific CD8 T cells in spleen and lymph nodes was much higher when compared to those in peripheral blood. Furthermore, KAV-specific CD8 T cells could specifically kill KAV-pulsed target cells in vivo but the efficiency was low. These data suggest that prime-boost vaccination schedule with peptide in Freund＇s adjuvant can elicit antigen-specific CD8 T cells of effector-like phenotype with partial functional exhaustion, which may only provide short-term protection against the pathogen. Cellular ＆ Molecular Immunology.

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