中文摘要：

目的：探讨低氧诱导分子-1α（HIF-1α）在新疆哈萨克族（哈族）食管鳞癌发生发展中的作用及其临床意义。方法：本研究收集了50例新疆哈族食管鳞癌组织和50例癌旁正常组织,采用免疫组织化学S-P法检测食管鳞癌和癌旁正常组织HIF-1α的表达。结果：新疆哈族食管鳞癌组织中HIF-1α的中-强阳性表达率为58%,明显高于癌旁正常组织的18%（χ~2=15.323,P〈0.001）;HIF-1α在食管鳞癌中的表达与患者肿瘤的浸润深度、脉管浸润、淋巴结转移及临床分期具有显著的相关性（P均〈0.05）。结论：HIF-1α的表达与新疆哈族食管鳞癌的发生和发展密切相关,HIF-1α的高表达预示哈族食管鳞癌的高侵袭性。

英文摘要：

Objective： To investigate the role of hypoxia-inducible molecule-1α（HIF-1α） in the development and progression of esophageal squamous cell carcinoma of Xinjiang Kazakh and its clinical significance. Methods：50 cases of Xinjiang Kazakh esophageal squamous cell carcinoma and 50 normal tissues were collected.Immunohis-tochemical S-P method was used to detect the expression of HIF-1α in esophageal squamous cell carcinoma and adjacent normal tissues. Results：The medium-strong positive rate of HIF-1α expression in Xinjiang Kazakh esophageal squamous cell carcinoma was 58%,which was significantly higher than that in adjacent normal tissues18%（χ^2=15.323,P〈0.001）. The expression of HIF-1α in Xinjiang Kazakh esophageal squamous cell carcinoma was significantly correlated with the depth of invasion, vascular invasion, lymph node metastasis and clinical stage（P〈0.05,respectively）. Conclusion：The expression of HIF-1α is closely related to the occurrence and development of Xinjiang Kazakh esophageal squamous cell carcinoma,and the high expression of HIF-1α predicts the high invasion of esophageal squamous cell carcinoma.