中文摘要：

假互补肽核酸（pseudocomplementary peptide nucleic acids，pcPNAs）是肽核酸（peptide nucleic acids，PNA）的一种衍生物，通过碱基修饰可以使pcPNAs 同时与双链DNA两条链中相应的靶序列结合；而在pcPNAs识别靶序列并结合时，pcPNAs自身两条链间由于空间位阻作用，不会自身互补结合. pcPNAs与DNA、RNA甚 至肽核酸相比具有独特的杂交特性，因此具有非常广泛的分子生物学效应.本文就pcPNAs寡聚体的结构、与核酸杂交的特点及杂交模式，分子生物学效应以及应用等 方面进行介绍.

英文摘要：

Pseudocomplementary peptide nucleic acids（pcPNAs） are the modified derivative of peptide nucleic acids（PNA）, the pcPNAs are therefore synthesized to contain 2,6-diaminopurine and 6-thiouracil instead of adenine and thymine. Due to steric hindrance, pcPNAs are unable to form pcPNA-pcPNA duplexes but can bind to complementary DNA sequences by Watson-Crick pairing via double duplex-invasion complex formation. pcPNAs have uniqe hybridization characteristics compared with DNA / RNA, and peptide nucleic acid ,so have a very wide range of molecular biological effects. This article overviewed pcPNAs oligomeric structure, hybrid characteristics , hybrid models, molecular biological effects and applications.