中文摘要：

将人鼠嵌合抗肿瘤细胞核单抗（chTNT-3）共价连接到多柔比星脂质体表面，制得的chTNT-3-空间稳定脂质体粒径分布为（123．1±28．4）nm，多柔比星包封率大于98％。初步稳定性考察表明，在低温（4℃）贮存7d，制品平均粒径及分布变化小，药物泄漏少于3％，免疫活性保持不变，理化性质尚较稳定。

英文摘要：

Chimeric TNT-3 monoclonal antibodies （chTNT-3） were covalently linked to the surface of doxorubicinentrapped liposomes to prepare chTNT-3 modified sterically stabilized liposomes. The size distribution of the product was （123.1 ± 28.4） nm and the entrapment efficiency was more than 98 %. The prepared liposomes showed rather stable physicochemical properties when stored at 4℃ for 7 days. Under this condition, liposome size and size distribution did not noticeably change, leakage of drug from liposomes was less than 3 %, and immunoreactivity was maintained.