中文摘要：

由于抗体所具有的高特异性和亲和力，抗体与肿瘤细胞表面的特异性抗原结合后，可通过不同的生物学作用抑制肿瘤细胞的生长．目前，治疗性抗体已成为肿瘤治疗中的一线治疗策略．截至2013年，美国FDA已批准了14种抗体药物用于临床肿瘤的治疗．随着肿瘤研究的不断深入，越来越多的参与肿瘤发生发展以及导致肿瘤免疫逃逸的分子陆续被发现，以这些分子为靶点，利用针对这些分子的特异性抗体进行肿瘤治疗，已成为目前肿瘤治疗研究的热点，同时也是转化医学最成功的范例之一．

英文摘要：

With high specificity and affinity, after binding with its specific antigen on tumor cell, antibody can inhibit the growth of tumor cell through different biological functions. Currently, an- tibody has become the first-line treatment strategy in cancer therapy. Until 2013, 14 antibodies have been approved by FDA to be used in clinic for cancer treatment. With the development of cancer research, more and more molecules that are involved in tumor progression or tumor immune escape have been found, and more and more scientists are working on developing therapeutic antibodies targeting these molecules. Therapeutic antibody has become the hot spot in tumor research, and one of the most successful examples in translational medicine.