中文摘要：

在许多癌症中， miR？34家族成员充当着极具潜力的具有肿瘤抑制活性的作用。例如，在肺癌中，外源性高表达miR？34a能够抑制肺癌细胞的增殖并诱导其凋亡。预示着利用miR？34a的恢复疗法（replace？ment therapy）治疗肺癌具有良好的前景，其作用机制也正在逐渐阐明。许多研究发现， miR？34a家族成员与肺癌细胞的增殖、转移、凋亡、细胞周期的调控息息相关。因此， miR？34a家族成员在肺癌的早期诊断、治疗、预后及发病机制的研究中发挥着重要作用。文章综述了miR？34家族的研究现状，重点总结了 miR？34家族在肺癌中的作用机制。

英文摘要：

MicroRNA-34 （ miR-34 ） family members play a tumor-suppressive role in many cancers-Over-expression of exogenous miR-34 a can inhibit the proliferation of and induce the apop-tosis of lung cancer cells-Recently, the replacement therapy of miR-34a has been found to be effec-tive for the treatment of lung cancer, and the mechanisms are gradually being elucidated-Numerous studies showed that miR-34a family members are involved in the proliferation, metastasis, apoptosis and cell cycles of lung cancer cells, suggesting the important roles of miR-34a family members in early diagnosis, treatment, prognosis and pathogenesis of lung cancer-Here, we reviews research status of miR-34 family members and highlights the action mechanism of miR-34 family members in lung cancer.