经皮冠状动脉介入治疗(PCI)是目前公认的治疗冠心病的有效手段,但是支架置入术后再狭窄严重影响了其临床疗效。研究证明,胶原的沉积在球囊扩张术和支架置入术后血管再狭窄的发生发展中起重要作用。因此,调节胶原合成、分解及参与的细胞因子和生长因子,可能为预防和治疗PCI后血管再狭窄提供新靶点和新思路。
Percutaneous transluminal coronary intervention(PCI) is recognized as an effective treatment for coronary heart disease currently.But in-stent restenosis limits its clinical efficacy.It′s demonstrated that collagen accumulation in the ECM plays a major role in the development of restenosis,after both balloon angioplasty and stenting.Factors regulating collagen synthesis and degradation,including various cytokines and growth factors involved in the process,may be new targets for therapies of in-stent restenosis.