中文摘要：

目的观察依达拉奉对心脏骤停（CA）大鼠心肺复苏（CPR）后远期生存及神经功能的影响。方法选择SD大鼠40只,随机分为盐水组及依达拉奉组各20只。盐水组及依达拉奉组经食管调搏诱发室颤至CA,5 min后给予胸外心脏按压及机械通气。按压1 min时给予肾上腺素0.04 mg/kg,恢复自主循环（ROSC）5 min后,经静脉分别给予盐水和依达拉奉3 mg/kg。观察ROSC后72 h内复苏大鼠的存活时间,并进行神经功能缺失评分。结果依达拉奉组生存时间为（70.0±26.7）h,长于盐水组的（23.0±3.9）h,P〈0.05;依达拉奉组大鼠在ROSC后12、24、48、72 h累积生存率分别为100%、90%、55%、45%,盐水组分别为60%、50%、30%、25%,两组各时点累积生存率比较,P均〈0.05;且72 h内神经功能缺失评分依达拉奉组高于盐水组（P均〈0.05）。结论依达拉奉可以延长CA大鼠CPR后的生存时间,提高其生存率,改善神经功能预后。

英文摘要：

Objective To observe the influence of edaravone on prolong survival and neurological function in a rat mode of cardiopulmonary resuscitation（CPR） after cardiac arrest（CA）.Methods Forty Sprague Dawley rats were randomly divided into two groups： saline group（n=20） and edaravone group（n=20）.Rats undergone CA induced by transesophageal pacing and untreated for 5 min.CPR and mechanical ventilation was implemented at the end of 5min for CA.Epinephrine（0.04 mg/kg） was administered at the first min of CPR.Animals were randomized to receive either saline or edaravone 3 mg/kg immediately at the restoration of spontaneous circulation（ROSC） through intravenous injection.The survival time,survival rate were recorded and neurological deficit scores（NDS） were assessed in the following 72 hours after ROSC.Results The median survival time in the edaravone group was（70.0±26.7） hours,which was significantly longer than the control group（23.0±3.9） hours（P〈0.05）.The cumulative survival rates after ROSC at 12,24,48 and 72 hours were 100%,90%,55% and 45% respectively in the edaravone group,and 60%,50%,30% and 25% respectively in the control group.There were significant differences between the control and edaravone groups（all P〈0.05）.The NDS in the edaravone group were better than those in the control group（all P〈0.05）.Conclusions Edaravone treatment immediately at ROSC can prolong the median survival time,meanwhile,improve the survival rate and the recovery of neurological function of CA rats after CPR.