中文摘要：

目的：探讨沙苑子水提取物对肾阳虚高脂血症模型大鼠的调脂作用及其可能的作用机制。方法10周龄雌性 SD 大鼠，随机分为6组，即正常组，模型组，雌激素组和沙苑子高、中、低剂量组，每组10只。除正常组外，其余各组大鼠实施双侧卵巢切除手术。术后，正常组大鼠给予普通饲料，其余各组给予高脂饲料。正常组和模型组灌胃生理盐水，雌激素组灌胃戊酸雌二醇（0．2 mg／kg），其余各组分别灌胃沙苑子提取物（136、68、34 mg／kg），持续给药8周。测量各组大鼠的体重，检测血清 TC、TG、HDL-C、LDL-C，血清雌激素（E2）、卵泡刺激素（FSH）及肝脏雌激素受体（ERα与ERβ）mRNA。结果与正常组相比，模型组大鼠在给予高脂饲料后第3周开始体重显著增加（P ＜0.001），血清 TC 与 LDL-C 从第5周、TG 与 HDL-C 从第7周开始明显增高（P ＜0．001，P ＜0．01，P＜0．001，P ＜0．05），血清 E2显著降低（P ＜0．01），血清 FSH 显著升高（P ＜0．05），肝脏 ERαmRAN的表达水平显著下调（P ＜0．05）。与模型组比较，沙苑子高剂量组从给药第7周 TC、TG 显著降低（P ＜0．05，P ＜0．001），中剂量组从给药第7周 LDL-C 显著降低、HDL-C 显著升高（P ＜0．05，P ＜0．01），低剂量组在给药第8周 HDL-C 显著升高（P ＜0．05）；沙苑子各剂量对血清 E2和 FSH 含量均没有明显的作用（P ＞0．05），但均显著上调肝脏 ER-αmRNA 的表达（P ＜0．05）。结论沙苑子具有调节血脂代谢的作用，其机制可能是通过上调雌激素受体的表达水平、放大受体传导的信号而实现的，这在一定程度上弥补了激素水平的不足，从而达到治疗围绝经期脂代谢紊乱的目的。

英文摘要：

Objective To explore the effect of water extracts from Semen Astragali Complanati （Flatstem Milkvetch Seed,hereinafter“SAC”）on lipid metabolism in hyperlipidemia model rats with kidney-yang deficiency pattern,so as to try to discover the mechanism.Methods Female 10-week-old SD rats were randomly divided into six groups （each n =10）：normal group,model group,estrogen group,SAC low-dose group,SAC mid-dose group and SAC high-dose group.The rat model was induced by bilateral ovariectomization combined with high-fat diet feeding.And rats of normal group and model group were in-tragastrically （i.g.）administered with saline,those of estrogen group were i.g.with estradiol valerate （0.2 mg/kg）,and three SAC groups were i.g.with SAC extract at the dose of 34,68 and 136 mg/kg＆amp;nbsp;for consecutive 8 weeks.The body weight of rats were recorded,serum TC,TG,HDL-C and LDL-C were measured and serum E2 ,FSH and estrogen receptors （ERα,ERβ）mRNA in liver tissue were de-tected.Results Compared with the normal group,the body weight of rats of model group increased sig-nificantly after three weeks’high-fat feeding （P 〈0.001 ）;from Week 5 the level of total cholesterol （TC）and low density lipoprotein cholesterol（LDL-C）increased significantly （P 〈0.001 or P 〈0.01）, and from Week 7 triglyceride（TG）and high density lipoprotein cholesterol（HDL-C）also did （P 〈0.001 or P 〈0.05）;serum E2 significantly decreased （P 〈0.01）,and follicle stimulating hormone（FSH）in-creased （P 〈0.05）,the expression of ER-αmRNA in liver significantly decreased（P 〈0.05）.High dose of SAC significantly reduced the serum level of TG and TC from Week 7 （P 〈0.05 or P 〈0.001）, middle dose of SAC reduced the level of LDL-C and increased HDL-C significantly at the same time point （P 〈0.05,P 〈0.01）,and a more week later,the low dose increased the serum level of HDL-C （P 〈0.05）.Despite the levels of E2 and FSH of model rats showed no significant difference after