中文摘要：

目的探讨核转录因子-κB（nuclear factorκB,NF-κB）在B细胞淋巴瘤组织中的表达及其与临床病理特征的关系。方法采用免疫组化法检测42例B细胞淋巴瘤组织（B细胞淋巴瘤组）及20例淋巴结反应性增生组织（对照组）中NF-κB蛋白的表达。分析NF-κB表达与B细胞淋巴瘤临床病理特征的关系。结果 NF-κB在B细胞淋巴瘤组织和淋巴结反应性增生组织中的阳性表达率分别为78.57%（33/42）和20%（4/20）,两组比较差异有统计学意义（P〈0.001）。NF-κB的表达与恶性程度、临床分期有关（P〈0.05）;而与年龄、性别、乳酸脱氢酶（LDH）水平无关（P〉0.05）。结论 NF-κB在B细胞淋巴瘤发生、发展中起重要作用,有望成为判断淋巴瘤患者预后的指标。

英文摘要：

Objective To investigate the expression of nuclear transcription factor κB（NF-κB）in B cell lymphoma, and analyze possible relationships between expression and clinicopathological characteristics. Methods Immunohistochemistry was used to detect NF-κB protein expression in tissues from 42 patients with B cell lymphoma and 20 patients with reactive lymph node hyperplasia. Relationships between NF-κB expression and clinicopathological characteristics were analyzed. Results The rate of NF-κB-positive tissue was significantly higher among patients with B cell lymphoma （78.57%,33/42） than among those with reactive lymph node hyperplasia （20% ,4/20; P〈0.001 ）. Level of NF-κB protein expression correlated with Ann-Arbor clinical stage and histology grade （P〈0.05）,but not with sex,age or lactate dehydrogenase （LDH）level （P〉0.05）. Conclusion NF-κB plays an important role in the development of B cell lymphoma, and it may serve as a prognostic indicator.