中文摘要：

目的：观察丹参酮ⅡA对高血压病血瘀证患者血清致伤ECV-304活性的影响。方法：将培养的人脐静脉内皮细胞株ECV-304按空白对照组、血瘀证组、TanⅡA40、20、10、5μg/mL组分组,MTT法检测ECV-304活性。结果：24h和48h血瘀组与空白对照组比较,细胞活性显著降低（P〈0.01）;24h和48h TanⅡA 10μg/mL组与血瘀组比较,细胞活性显著增强（P〈0.05,或P〈0.01）。结论：高血压病血瘀证患者血清可以损伤内皮细胞,丹参酮ⅡA对内皮细胞具有保护作用。

英文摘要：

Objective： To observe the effects of tanshinone ⅡA on activity of serum injury ECV-304 cell in patients with blood stasis syndrome of hypertension.Methods： Cultural ECV-304 strain were divided into the control group,the blood stasis syndrome group,the TanⅡA 40μg/mL group,the TanⅡA 20μg/mL group,the TanⅡA 10μg/mL group and the TanⅡA 5μg/mL group,the activity of ECV-304 of each group was detected with MTT.Results： The blood stasis syndrome group compared with the control group after 12 hours and 24 hours,the cell activity value decreased markedly（P〈0.01）;The Tan ⅡA 10μg/mL group compared with the blood stasis syndrome group after 12 hours and 24 hours,the cell activity value increased markedly（P〈0.05 or P〈0.01）.Conclusions： The serum of patients with blood stasis syndrome of hypertension can injury the activity of Ecs,but the tanshinone ⅡA can safe the activity of Ecs.