中文摘要：

目的分析青年结直肠癌患者的临床和病理特征。方法回顾性分析南京医科大学第一附属医院2006年至2016年122例青年结直肠癌患者的临床资料。结果 122例患者中,中位年龄30岁,男女比例为1.3：1;首发症状主要为便血、腹痛、肠梗阻;病变部位以低位多见;大体类型主要为溃疡型;病理组织分型以腺癌和黏液腺癌多见;分化程度以中低分化为主;确诊时多为中晚期;误诊或漏诊患者65例,占53.3%;部分患者伴有胆囊炎、慢性阑尾炎或脾脏增大;治疗方法主要为根治性手术。本组青年结直肠癌患者左右半结肠癌的对比分析中,首发症状（P〈0.01）及伴随症状差异存在显著统计学意义（χ^2=13.335,P=0.001）;而不同性别的青年结直肠癌患者的临床及病理特征方面差异无显著统计学意义。结论青年结直肠癌临床症状隐匿,误诊率高,肿瘤细胞分化低,恶性程度高,预后差,应提高青年结直肠癌的警惕性,早诊断,早治疗。

英文摘要：

Objective To explore the clinical pathological characteristics of colorectal cancer in young patients. Methods The Clinical data of 122 young patients with colorectal cancer in The First Affiliated Hospital with Nanjing Medical University from 2006 to 2016 were retrospectively reviewed. Results 122 patients were collected in the study, the mean age was 30 years old. Among them with male to female ratio of 1.3 to 1.The main symptoms were bloody stools, abdominal pain, intestinal obstruction. The tumors mostly located in the rectum and sigmoid colon. In gross type, ulcerative type was in majority in the young age group. In these young patients, most of them had adenocarcinoma and mucinous adenocarcinoma. The degree of differentiation was mainly middle-low differentiation. The young patients were diagnosed mostly in the advanced stage. The misdiagnosis or missed diagnosis rate of young patients was high, about 53.3%.Some patients of them with cholecystitis, chronic appendicitis or spleen enlargement. The main treatment is radical operation. There were significant differences in the main symptoms（P〈0.01） and concomitant symptoms（χ^2=13.335, P=0.001） between left colon cancer and right colon cancer in this study. However, there were no significant differences in the clinical and pathological features of colorectal cancer among young men and women of different genders. Conclusion The atypical clinical symptoms, high misdiagnosis or missed diagnosis rate, poor differentiation, higher malignant degree, poor prognosis are all characters in young patients. We should pay attention to the occurrence of colorectal cancer in young patients, in order to have early diagnosis and treatment.