中文摘要：

淀粉样蛋白纤维是一类纤维状的蛋白质聚集体，与多种蛋白质沉积疾病相关．对淀粉样蛋白纤维结构的研究，有助于人们从分子水平上阐述其形成机理，提供相关疾病预防或治疗的依据．由于淀粉样蛋白纤维不可溶、非结晶，因此液体核磁共振和x～射线衍射等方法对这类体系的应用受限，而固体核磁共振被认为是研究这类体系最具前景的技术．该综述介绍了固体核磁共振解析蛋白质结构的方法及其应用于淀粉样蛋白纤维体系的研究进展．

英文摘要：

Amyloid fibrils are fibriform aggregates of amyloid proteins, which are impli- cated in many protein deposition diseases. Knowing the structures of amyloid fibrils will shed light on the molecular mechanism of fibrillation, facilitating the prevention and therapy of related diseases. Solid-state NMR is the most prospective technique for eluci- dating the structures of amyloid fibrils, since they are insoluble and non crystalline such that they are difficult to be studied by liquid-state NMR and X-ray diffraction approaches. In this paper, recent progresses on using solid-state NMR methods to elucidate structural information of proteins, especially amyloid fibrils, are reviewed.