中文摘要：

目的：评价芍药舒筋片对大鼠膝关节炎关节软骨病理改变及PⅡCP水平的影响。方法：将50只大鼠随机分成假手术组、模型组和受试药高、中、低荆量组，采用经典ACLT手术造模，手术后第2天灌胃给药4周后，腹主动脉取血，分离血清及取术侧膝关节。结果：通过Mankin评分提示，芍药舒筋片受试药组评分均小于模型组，与模型组比较差异有统计学意义（P〈0．05）；通过ELlSA检测血清PIICP浓度的统计提示，芍药舒筋片受试药组与模型组比较差异有统计学意义（P〈0．05）。结论：芍药舒筋片对大鼠膝骨关节软骨有一定的保护作用，可一定程度的预防膝骨关节炎关节软骨退变。

英文摘要：

To evaluate the effect of Shaoyao Shujin pill （SSP） on the pathology of articular cartilage and the level of PⅡ CP of rats with knee osteoarthritis. Methods：Fifty SD rats were randomly divided into 5 groups： normal group, model group, and three experimental groups （the high-dose group, the mid-dose group, and the low-dose group）. The ACLT operation was applied to make knee osteoarthritis model, and they were intragastric administration 2 days after surgery. Abdominal aortic blood was sep- arated and the surgery side of knee was taken after 4 weeks. Results：The Mankin score and the level of PⅡCP were statistically dif- ferent between the test group and the model group （P〈0.05）. Conclusion： Shaoyao Shujin pill can protect articular cartilage and prevent the degeneration of knee osteoarthritis of articular cartilage.