中文摘要：

目的观察饲喂不同剂量的碘化钾与碘酸钾的大鼠血浆抗氧化能力相关指标的变化。方法将116只Wistar大鼠随机分为8组,碘化钾与碘酸钾各设4个剂量组：适量剂量组、10倍剂量组、50倍剂量组和100倍剂量组。实验大鼠饲喂12个月后,检测血浆中超氧化物歧化酶（SOD）活性、谷胱甘肽过氧化物酶（GSH-Px）活性和丙二醛（MDA）含量。结果碘化钾组：SOD活性,50倍组低于适量组;GSH-Px活性,100倍组高于适量组;MDA含量,50倍组与100倍组均低于适量组;碘酸钾组：各指标高剂量组与适量组比较无统计学差异;不同碘剂相同剂量组间,SOD与GSH-Px活性100倍碘酸钾组均低于100倍碘化钾组。其余各组无统计学差异。结论高剂量的碘化钾与碘酸钾均会对大鼠血浆抗氧化系统产生影响;血浆中抗氧化系统复杂,其机制有待进一步的研究。

英文摘要：

Objective To study the effect of different dosages potassium iodide and potassium iodate on the antioxidative capability of rat blood plasma.Methods The rats were divided into 8 groups.4 groups of them given by different dosages of potassium iodide,and another 4 groups were given by different dosages of potassium iodate.The groups were normal dosage（KI and KIO3）,10 fold high dosage（10KI and 10KIO3）,50 fold high dosage（50KI and 50KIO3） and 100 fold high dosage（100KI and 100KIO3）.12 months later,the rats were sacrificed and superoxide dismutase（SOD） activity,glutathione peroxidase（GSH-Px） activity and malondialdehyde（MDA） content were measured.Results After treatment for 12 months,the statistic differences among different dosage groups with the same drug were compared by SPSS13.0.The SOD activity of 50KI group was markedly lower than that in KI group.Furthermore,the GSH-Px activity of 100KI group was higher than that in KI group.The MDA content of 50KI and 100KI groups were both lower than that in KI group after administration for 12 months.After comparison between two compared groups of the same dosage with different drug,the SOD and GSH-Px activity of 100KIO3 were both markedly lower than that in 100KI group.No difference was found between other compared groups.Conclusion Both of high dosage potassium iodide and potassium iodate influence the antioxidative capability of rat blood plasma.Compare to potassium iodide,the potassium iodate is more likely to cause the disbalance of the antioxidative system in blood plasma.