中文摘要：

目的应用磁共振成像（MRI）的弥散张量成像（diffusion tensor imaging,DTI）技术,研究和探讨脑出血后锥体束继发性损害的发生发展规律及其临床意义。方法连续收录2010年7月～2013年1月住院治疗且脑出血患者12例为实验组和选择性别、年龄与实验组相匹配的健康志愿者12例做为对照研究。分别进行DTI检查,实验组和对照组DTI数据采用t检验;各个时间点数据之间的两两比较用LSD方差分析法。结果所有实验组患者在DTI的FA图上,同侧病灶锥体束平面上,均可见信号减弱。FA值与对照组比较,各时间点明显减少（P〈0.01）,而MD值却无明显变化。结论 DTI不仅可以以可见的图像清楚地显示脑出血后锥体束继发性损害,还可以用数据的形式精确量化这种损害的程度,并发现继发性损害会随时间延长而逐渐加重,有可能阻碍患者的神经功能恢复。

英文摘要：

Objective To idal tracts （PT） imaging （MRI） after cerebral and diffusion explore the occurrence and development of the secondary degeneration of pyramhemorrhage and its clinical significance by using conventional magnetic resonance tensor imaging （DTI） techniques. Methods Twelve patients with cerebral hemorrhage admitted to our hospital from Jul. 2010 to Jan. 2013 were enrolled in the experimental group. All the patients underwent conventional MRI and DTI. Twelve age-- and gender-- matched volunteers underwent DTI at the same time were selected as controls. Mean diffusivity （MD） and fractional anisotropy （FA） were measured at the region of interest （ROI）. t test was used to perform comparison of DTI data （FA values） be- tween experimental group and control group. Repeat measurement was established to reveal the time course of clinical scores and DTI quantitative data. Used LSD analysis of variance to perform comparison between group means at each time points. Results In DTI scanning, on the map of FA, intensive signal decreased in the PT of the ipsilateral cerebrum in all cases of experimental group. Compared to control group, patients of experimental group in FA values of lesion site at every time points, the ipsilateral proximal significantly decreased （ P 〈0.01）, while the MD was not significantly different at any time points. Conclusion The secondary degeneration of PT after cerebral hemorrhage can be revealed on MRI, DTI not only can demonstrate it clearly with the map of FA, but also can identify and quantify the secondary degeneration with the precise data of the FA value. Our findings indicated that the secondary degeneration is more serious as disease prolonged, which may hamper the neurological recovery.