中文摘要：

目的：本研究旨在探讨原发性中枢神经系统淋巴瘤的诱导及巩固治疗,以期提高临床上对此类淋巴瘤的认识,为系统治疗提供经验。方法：报道1例原发性中枢神经系统弥漫大B细胞淋巴瘤患者的临床特征和诊治过程,同时结合国内外文献进行相关分析。结果：1例原发性中枢神经系统弥漫大B细胞淋巴瘤患者接受以大剂量甲氨蝶呤为主的多药联合化疗,并续贯2次含噻替派的大剂量化疗联合自体造血干细胞移植,取得显著的临床疗效,移植后患者处于持续缓解状态。结论：原发性中枢神经系统淋巴瘤是一类少见的原发于颅脑的恶性淋巴瘤。年轻患者在获得缓解后尽快接受含噻替派的大剂量化疗联合自体干细胞移植是首选的治疗策略。

英文摘要：

Objective： To explore the induction chemotherapy and consolidation therapy for primary central nervous system lymphoma （PCNSL）, and in order to improve the clinical understanding of this type of lymphoma, and to provide experiences in systemic therapy. Methods： A case of diffuse large B-cell PCNSL was reported. The clinical features, diagnosis and the treatment were reviewed, and the relevant literatures were reviewed and discussed. Results： The patient with diffuse large B-cell PCNSL was treated with high-dose methotrexate-based induction chemotherapy, then sequentially received two courses of high-dose chemotherapy （HDC）with thiotepa/autologous stem cell transplant （ASCT）, and achieved significant clinica efficacy with sustained remission after transplantation. Conclusion： PCNSL is a group of uncommon primary brain tumors. Thiotepa-based HDC/ASCT as consolidation therapy may play an important role in improvement of prognosis, especially for young patients.