中文摘要：

喜树碱具有抗肿瘤活性,但毒副作用和水溶性差限制了它的使用,有必要对其进行结构上的修饰。该文总结了近年来喜树碱及其衍生物的合成与活性研究方面的最新进展。

英文摘要：

Camptothecin（CPT） possess antitumor activity. The application of this compound is significantly limited because of its high toxicity and low solubility in water, so it is necessary to modify the molecular structure of CPT. This paper summarized the synthesis and antitumor activity of camptothecin and its derivatives in recent years.