中文摘要：

目的：研究美洲大蠊提取物对BALB/c荷瘤小鼠脾淋巴细胞的影响。方法：灌胃给予BALB/c荷瘤小鼠低、中、高剂量的（50、100、200mg/kg）美洲大蠊提取物（EPA），阳性组给予环磷酰胺（CTX，50mg/kg），给药10d后处死小鼠，测定小鼠脾脏中T淋巴细胞和外周血中LY、MO、GR细胞的含量，并计算抑瘤率。结果：EPA能增加脾脏中CD8+的含量，与模型组相比，明显提高肿瘤生长抑制率（P<0.05）。结论：美洲大蠊能抑制H22肝癌小鼠的肿瘤生长，其机制可能与脾脏中CD8+含量增加有关。

英文摘要：

Objective:To study the effects of Periplanet americana extract on spleen lymphocytes of H22Tumor-bearing mice.Methods:BALB/c mice were administered with low dose,middle dose and high dose of Periplaneta americana extract(50,100,200mg/kg)by gavage.The positive group was injected with50mg/kg cyclophosphamide.After10-day feeding and injection respectively thecontent of T lymphocytes in the spleen,lymphocyte cells,Monocyte cells and granulocyte cells in peripheral blood were measured,andthe anti-tumor rate was calculated.Results:The Periplaneta americana extract could obviously increase the content of CD8+and thetumor growth inhibition rate(P<0.05)compared with the normal group.Conclusion:Periplaneta americana extract can inhibit thegrowth of H22liver tumor in mice and its mechanism may be related to the increase of the content of CD8+in the spleen.