研究了在新型催化剂淀粉磺酸酯(SSA)作用下以芳香醛、乙酰丙酮、尿素为原料,水为溶剂,50℃下的Bigi-nelli反应,合成了系列3,4-二氢嘧啶-2(1H)-酮衍生物.该反应具有原料易得、反应时间短、条件温和、收率较高等优点,是一种洁净的合成方法.
In this paper, the Biginelli reactions of aldehyde, pentane-2, 4-dione and urea catalyzed by starch sulfonic acid (SSA) are studied and a series of 3,4-dihydropyrimidine-2(1H)-ones derivatives are synthesized in higher yields under milder conditions and in shorter time.