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中文摘要：
应用RT-PCR、Westem blot、免疫组化分别检测甲状腺乳头状癌组织与癌旁正常甲状腺组织标本中DcR3mRNA及蛋白的表达情况，探讨DcR3在甲状腺乳头状癌组织中的表达及，临床意义。RT-PCR检测显示，甲状腺乳头状癌中DcR3 mRNA的表达明显高于正常甲状腺组织（P〈0．05）：Western blot提示，DcR3蛋白在甲状腺乳头状癌中表达比正常甲状腺组织高（P〈0．05）；免疫组化显示，DcR3蛋白在甲状腺乳头状癌中高表达（P〈0．05）。DcR3mRNA及蛋白质在甲状腺乳头状癌及正常甲状腺组织间的表达差异有统计学意义（P〈0．05）。DcR3基因及蛋白在甲状腺乳头状癌中高表达，提示DcR3可能促进了甲状腺乳头状癌的发生发展。
英文摘要：
To explore the expression of DcR3 and it＇s clinical significance in papillary thyroid carcinoma, the expression of DcR3 mRNA in papillary thyroid carcinoma （n=50） and adjacent normal thyroid tissue （n=50） was detected by RT-PCR, and DcR3 protein was detected by Western blot and immunohistochemistry. RT-PCR result showed that the expression of DcR3 mRNA in papillary thyroid carcinoma tissue was higher than normal thyroid tissue （P〈0.05）; Western blot and immununohistochemistry （IHC） results showed DcR3 protein expressed higher in papillary thyroid carcinoma （P〈0.05）. DcR3 overexpressed both in mRNA and protein level in papillary thyroid carcinoma, it suggests that DcR3 may promote the formation and progress of papillary thyroid carcinoma.
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