中文摘要：

目的 探讨乌鸡黑色素对于6-羟多巴胺（6-OH-DA）单侧损毁纹状体诱导的帕金森病模型大鼠的神经保护作用及其机制。方法 将60只SD大鼠造模成功后,随机分为对照组、6-OH-DA诱导的帕金森病单纯模型组和治疗组,治疗组分别按6 mg/kg或20 mg/kg乌鸡黑色素灌胃给药,1次/d,共3 w。然后比较各组中脑黑质多巴胺能神经元的数目、纹状体酪氨酸羟化酶（TH）阳性神经纤维的数量、阿朴吗啡诱导的旋转行为以及大鼠自主运动情况的差异。结果 6 mg/kg和20 mg/kg乌鸡黑色素灌胃给药能显著减少6-OH-DA所导致的中脑黑质多巴胺能神经元的死亡,减少纹状体TH阳性神经纤维的丢失,并有效改善阿朴吗啡诱导的旋转行为。结论 乌鸡黑色素能缓解6-OH-DA诱导的中脑黑质多巴胺能神经元的损伤,对于帕金森病有潜在的治疗作用。

英文摘要：

Objective To investigate the protective effect of melanin derived from black-bone silky fowl （BSF） on 6-OH-DA unilateral striatum induced rat models with Parkinson＇s disease （PD） and its mechanism, Methods Totally 60 SD rats were taken to establish the models and randomly divided into 3 groups, i.e. control group, 6-OH-DA induced PD model group, and treatment group. The control group received intragastric administration with 6 mg/kg or 20 mg/kg BSF melanin once per day for totally three weeks. Comparison was made in the number of midbrain substantia nigra dopaminergic neuron, the amount of striatum tyrosine hydroxylase （TH） positive fiber, the rotational behavior induced by apomorphine, and the rats＇ autokinetic movements among the three groups. Results The intragastric administration with 6 mg/kg and 20 mg/kg BSF melanin could significantly reduce the decease of the midbrain substantia nigra dopaminergic neuron induced by 6-OH-DA and the loss of striatum TH positive fiber. It also effectively improved the rotational behavior induced by apomorphine. Conclusion Melanin derived from BSF can relieve the damage in midbrain substantia nigra dopaminergic neuron reduced by 6-OH-DA. It has a potential therapeutic effect on PD.