中文摘要：

放射治疗是很多类型的恶性实体肿瘤的标准治疗方法之一,但是放射治疗除了存在一些严重的副作用以外很多恶性肿瘤细胞还具有抵抗放射线的功能,这就导致放射线治疗的局限性以及疗效的减弱。组蛋白超乙酰化作用可以使紧缩的核小体变得松弛,调控细胞凋亡及分化相关基因（Bim and Bmf）的表达,诱导细胞凋亡及分化,增强恶性肿瘤细胞对于放射线的敏感性。组蛋白去乙酰化酶抑制剂可以诱导组蛋白超乙酰化,用于恶性肿瘤的治疗,同时组蛋白去乙酰化酶抑制剂作为放射增敏剂有明显的抗肿瘤作用,并减少放射线治疗的剂量级照射时间,明显减轻放射线引起的副作用。组蛋白去乙酰化酶抑制剂很有可能成为肿瘤分子治疗的新靶点。检索近年来的SCI文章,国内外的学者主要是在蛋白质层面阐述组蛋白去乙酰化酶抑制剂作为放射增敏剂抗肿瘤作用机制,本文首次提出组蛋白去乙酰化酶抑制剂增强放射线促进恶性肿瘤细胞凋亡的特定基因（Bim and Bmf）并结合最新的组蛋白去乙酰化酶抑制剂分类进行综述。

英文摘要：

Radiotherapy is a standard treatment for various malignant tumors cell. However, there are considerable numbers of radioresistant carcinoma cells and severe adverse effects occasionally occur after radiation therapy. Histone hyperacetylation regulate apoptosis and differentiation-related gene（Bim and Bmf）and protein expression and stability, induce apoptosis and differentiation.Histone deacetylase inhibitors can be used for the treatment of malignant tumors, at the same time it is also a radiation sensitizer, can be combined with radiation therapy to improve the efficacy. Histone deacetylase inhibitor as radiation- sensitizers have significant anti-tumor effect, and is likely to become a new target of molecular cancer therapeutics.