中文摘要：

ABC转运蛋白家族是一个广泛存在于不同生物细胞中且功能保守的膜蛋白亚家族；它们是一类单向底物转运泵，通常以主动转运方式完成多种分子的跨膜转运。随着抗生素合成基因簇相关研究的开展，越来越多的簇内ABC转运蛋白被鉴定出来，对其生物学功能的研究正逐渐成为热点。多烯类抗生素作为一类重要的抗真菌药物，能够有效避免真菌产生耐药性，具有非常重要的临床价值。本文以多烯类抗生素合成基因簇为对象，综述了在其中所发现的ABC转运蛋白的研究进展，综合分析了其结构特性与功能间的关系，并对研究应用进行了展望。

英文摘要：

ATP-binding cassette （ABC） transporters are members of a protein superfamily that is one of the largest and most ancient families with great variety of functions. They are involved in trans- porting different substrates across the plasma membrane. As more ABC transporters were identified from the gene clusters for antibiotic biosynthesis, recent studies have begun to focus on their bio- logical functions. The polyene antibiotics represent a class of biologically active fungal metabolites synthetized by the genus Streptomyces. As drug resistance to polyene remains rare, polyene antibiot- ics have been the cornerstone of therapy for critically ill patients with invasive fungal infections. We reviewed the latest research progresses on ABC transporters of polyene antibiotic biosynthesis gene clusters, including their structure characteristics and biological functions. The potential relationship between the secondary structure and their function is also discussed.