中文摘要：

遗传性肾炎（hereditarynephritis，HN）是一组与遗传有关，主要累及肾小球的肾脏疾病，常伴有其它器官的损伤．HN呈家族聚集性，可表现为常染色体显性遗传、常染色体隐性遗传和X连锁遗传，有些家系还表现为非孟德尔遗传和线粒体遗传．对HN主要疾病的临床表型、遗传学和动物模型的总结和对HN疾病的深入研究有可能找到疾病的致病突变，以及更好地了解疾病的分子机制．

英文摘要：

Hereditary nephritis （HN） is a group of inherited kidney disorders involving glomerulus and other organs. A familial aggregation in some families suggested autosomal dominant inheritance, autosomal reces- sive inheritance and X-linked inheritance. Non-Mendelian and Mitochondrial inheritance patterns also have been observed in some families. Discussion of the clinical feature, the genetics and animal model of major types of HN and further analyses of HN may lead to the identification of disease-causing mutations and a better understanding of the molecular mechanisms in HN.