中文摘要：

目的：探索前庭信息是否调节前边缘皮质（prelimbic cortex，PrL）区神经元的活动。方法：体重130—150g雄性sD大鼠，分成两组：对照组和运动刺激组。运动刺激组动物接受2h双轴旋转运动刺激，以刺激前庭感受器。采用全细胞脑片膜片钳技术，分别在电流钳和电压钳模式下，刺激PrL浅层（Ⅱ／Ⅲ层）并记录PrL深层（Ⅴ／Ⅵ层）神经元，分析动作电位（action potential，AP）特性和诱发的兴奋性突触后电流（evoked excitatory postsynaptic current，eEPSC）。结果：2h双轴旋转刺激没有改变PrL神经元AP阈值、幅值、半幅时程、峰值上升相最大斜率以及峰值下降相最大斜率等参数（P〉0．05，n=10）；但向神经元输入波宽180ms，80～280pA的脉冲电流后，旋转刺激组PrL神经元放电数目显著增加（P〈0．05，n=8）。结论：前庭信息可影响PrL神经元活动，故PrL很可能是接受和处理前庭信息的高级脑结构之一。

英文摘要：

Objective： To investigate whether vestibular signals modulate the neuronal activities in prelimbic cortex （PrL） of rat. Methods： Male Sprague-Dawley rats, 130- 150 g, were used and divided into two groups： control and motion-stimulated groups, and animals in the later group were subjected to double-axes rotation for 2 hours which stimula- ted vestibular end organs. In whole cell patch mode on brain slices, superfacial layers （ layers Ⅱ and Ⅲ） were stimulated and neurons in deep layers （layers Ⅴ and Ⅵ） were recorded. Properties of action potentials （AP） and evoked excitatory postsynaptic currents （eEPSCs） were obtained and analyzed. Results： Two-hour doube-axes rotation did not alter the fol- lowing AP-related parameters ： AP threshold, amplitude, half-width, maximum rise slope and maximum dacay slope （P 〉 0.05, n = 10） ; however, intracellular current pulses ranging from 80 -280 pA with duration of 180 ms evoked significant difference in the number of spike firing in the cases where anminals received 2 h double-axes rotation （P 〈 0.05, n = 8）. Conclusion： Vestibular signals exert modulatory action on PrL neurons and PrL is likely one of the higher cortical areas that receive and process vestibular signals.