中文摘要：

目的通过功能磁共振（fMRI）技术,探讨精神分裂症患者静息状态下与基底节异常连接的脑区.方法采用3.0T功能磁共振成像技术检测15例精神分裂症患者与12例正常对照组在静息状态下的全脑功能活动.采用功能连接分析对比两组被试的基底节（双侧尾状核、壳核和苍白球共6个区域）与全脑功能连接的差异.结果与对照组相比,精神分裂症患者的内侧额上回、后扣带与尾状核的功能连接上升;左侧额上回、右侧前扣带与左侧苍白球功能连接上升;左内侧额上回与右侧苍白球功能连接上升;左侧额上回与左侧壳核功能连接上升.差异均有统计学意义.结论精神分裂症患者的基底节区域与默认网络的重要节点功能连接上升,提示基底节一默认网络环路出现异常,这可能与精神分裂症的病理机制有关.

英文摘要：

Objective To explore the difference of functional connectivity of basal ganglia in schizophrenia during a resting state by functional magnetic resoncance imaging(fMRI). Methods 3. 0T fMRI was used to assess the whole brain activity of 15 schizophrenia patients and 12 health controls. Functional connectivity analysis based on basal ganglia was performed to obtain the significant differ-ence between two groups. Results Compared with the health controls,the patients showed significantly increased functional connectiv-ity between media superior frontal gyrus,posterior cingulate and caudate;increased functional connectivity between left superior frontal gyrus,right anterior cingulate and left pallidum;increased functional connectivity between left medial frontal gyrus and right pallidum;increased functional connectivity between left superior frontal gyrus and left putamen. Conclusion This study discovers increased func-tional connectivity between basal ganglia and crucial regions of Default Model Network(DMN). The results imply that basal ganglia -DMN loop altered aberrantly,which might be associated with the pathological mechanisms of schizophrenia.