中文摘要：

以ZnO微球为模板，利用层层自组装的方法制备了壁材为鱼精蛋白（PRM）和硫酸葡聚糖（DXS）的生物可降解聚电解质胶囊．ZnO微球呈良好的单分散性，具有5nm以上的中孔，装载荧光素后生成荧光微球．在ZnO微球外交替吸附鱼精蛋白和硫酸葡聚糖，制得核-壳型ZnO／（DXS／PRM）。复合微球；采用稀HAC溶液去除ZnO模板后，可生成（DXS／PRM）8胶囊．以水溶性多柔米星药物分子作为目标物，研究了该胶囊的载药和释放行为．结果显示，该（DXS／PRM）8胶囊对多柔米星药物分子具有明显的缓释性．

英文摘要：

Ultrathin polyelectrolyte capsules were produced by layer-by-layer assembling of biodegradable polyelectrolytes, dextran sulfate （DXS） and protamine （PRM）, on ZnO microspheres followed by the cores decomposition with dilute HAC solution. ZnO microspheres were well mono-dispersed and had around 5 nm intermediate size pores, which could be used as fluorescein delivery. PRM and DXS formed regular growing stable multilayers on ZnO microspheres, thus formed ZnO/（DXS/PRM）8 core-shell microspheres. After removal of ZnO template, （DXS/PRM）8 capsules were fabricated. The loaded drug amount and controlled release behavior of hollow capsules were examined in the sample of dexorubicin hydrochloride （DOX）. The result shows that （DXS/PRM）8 demonstates obvious controlled release of DOX drug.