中文摘要：

目的采用血氧水平依赖功能磁共振成像技术（BOLD-fMRI）研究大脑对燃烧香烟气味的刺激反应。方法 26名男性右利手被试,其中吸烟者13人,不吸烟者13人。采用组块设计,应用单次激发梯度回波EPI序列采集,将燃烧的香烟气味输送到被试鼻孔作为刺激,自然呼吸空气为对照,用MRIcron、SPM8和Talairach Daemon软件进行数据处理。结果 1吸烟者和不吸烟者共同激活额叶（右侧额上回、左侧额中回、左侧中央前回）、顶叶（右侧顶下小叶、右侧缘上回）、左侧颞中回、右侧海马旁回和右侧丘脑;2吸烟者另外激活右侧中央前回、左侧扣带回、左侧楔前叶、左侧尾状核、左侧丘脑和小脑（左侧嘴峰、双侧小脑扁桃体、右侧下半月小叶）;3不吸烟者另外激活右侧额中回、左侧额下回、左侧额内侧回和左侧顶上小叶。结论燃烧香烟气味均能激活吸烟者与不吸烟者额叶、顶叶及中脑边缘系统,但具体脑区定位有差异;在中脑边缘奖赏相关脑区,吸烟者激活比不吸烟者明显;燃烧香烟气味激活吸烟者与不吸烟者脑区半球优势不同。

英文摘要：

Objective To study the brain response to the cigarette odor using blood oxygen-level dependent functional magnetic resonance imaging（BOLD-fMRI）. Methods Twenty-six right handed male subjects including 13 smokers and 13 non-smokers were scanned with single-shot gradient echo EPI fMRI. During the test cigarette smoke was sent to the tested nostril as the stimuli and fresh air as control. The data were processed with MRIcron, SPM8 and Talairach Daemon programs. Results 1 Smokers and non-smokers were both activated in the following regions： right superior frontal gyrus, left middle frontal gyrus and left precentral gyrus in the frontal lobe; right inferior parietal lobule and right supramarginal gyrus in the parietal lobe; right parahippocampal gyrus; left middle temporal gyrus; and right thalamus. 2 Smokers but not non-smokers were activated in： right precentral gyrus in the frontal lobe; left cingulate gyrus and right parahippocampal gyrus in the limbic lobe, left precuneus, left caudate nucleus, left thalamus, and left cerebellum（left cerebellar culmen, bilateral cerebellar tonsil, right inferior semi-lunar lobule）. 3 Non-smoker, but not smoker, were activated in the other frontal lobe region including right middle frontal gyrus, left inferior frontal gyrus, left medial frontal gyrus, and right superior parietal lobule. Conclusions Both smokers and non-smokers were found activated on frontal lobe, parietal lobe, and limbic lobe, with differences in specific brain areas. smokers were found to be activated more obviously in the reward related brain areas in the mesolimbic-system. Smokers and nonsmokers showed difference in hemispheric lateralization when exposed to cigarette odor.