中文摘要：

氧和铁这两种元素对生命活动十分重要.低氧诱导因子（hypoxia-inducible factors,HIFs）作为转录因子,参与一系列靶基因的表达调控以适应低氧.铁参与DNA合成、氧气运输、代谢反应等多种细胞活动,过量游离铁会通过Haber-Weiss或Fenton反应产生毒性自由基.细胞通过与铁吸收、存储和利用有关的多种铁代谢相关蛋白之间的协同作用来维持铁稳态.与铁稳态相关的一些基因是HIFs的靶基因或者间接受低氧调控,包括转铁蛋白、转铁蛋白受体、二价金属转运体1、铁调素、膜铁转运蛋白、血浆铜蓝蛋白、铁蛋白等,而胞内铁浓度的改变能影响HIFs的表达.本文就低氧与铁代谢相关蛋白的关系,尤其是低氧对铁代谢相关蛋白的调节作一综述.

英文摘要：

Iron and oxygen are essential substances for cellular activities in body tissues. Hypoxia- inducible factors （HIFs） , one kind of transcription factors that respond to available oxygen changes in the cellular environment, specifically at hypoxia conditions, regulate the transcription of a series of target genes. Iron participates in a wide variety of metabolic processes, including DNA synthesis, oxygen transport and electron transport. Excess amount of free iron may result in the formation of free radicals via Haber-Weiss or Fenton reactions, then induce cell injury and cell death. The coordinated regulation of iron metabolism-associated proteins for iron absorption, storage and utilization is critical for the maintenance of cellular iron homeostasis. The genes involved in iron homeostasis, including transferrin （TF）, transferrin receptor （TFR）, divalent metal transporter 1 （DMT1）, hepcidin （HAMP）, ferroportin 1 （FPN1） , ceruloplasmin （CP） , ferritin （FT） , are the target genes of HIFs, although some of which are regulated indirectly under hypoxia. The changes of intracellular iron concentration also modulate the expression of HIFs. This review discusses the relationship between hypoxia and iron metabolism-associated proteins, special focuses on the regulation of iron metabolism-associated proteins.