中文摘要：

慢性肾病是心血管疾病的高危因素。高磷血症与心血管疾病及血管钙化患者死亡率密切相关。升高的血清磷能够直接作用于血管平滑肌细胞进而促进血管钙化。血管钙化导致心血管疾病发生和发展,最终影响慢性肾脏病（CKD）患者的生存率。因此,早期发现CKD患者血管钙化,积极干预钙化危险因素,对于减少CKD患者心血管事件发生,提高生存质量有重要意义。本文主要综述血管钙化机制的新的研究进展,以及新药的发现控制患者血清磷对于防治血管钙化的效果。

英文摘要：

Hyperphosphatemia is a major cause of morbidity and mortality in patients with chronic kidney disease.The association between hyperphosphatemia and increased risk of death from cardiovascular disease/vascular calcification has been well established for a long time. Elevated serum phosphorus can act directly on vascular smooth muscle cells thereby promoting vascular calcification.Vascular calcification led to the development and progression of cardiovascular disease, and ultimately affect the survival rate of patients with CKD.This review explores the new aspects of pathogenesis of vascular calcification, as demonstrated by recent advances showing a recognized regulating role of phosphorus in vascular smooth muscle cell calcification. This novel mechanism may help in finding a new pharmacological therapy to reduce, or prevent blood vessel calcification.