中文摘要：

目的测定创伤性脑损伤患者血清泛素羧基末端水解酶L1（UCH—L1）和神经元特异性烯醇化酶（NSE）的含量，探讨其临床意义。方法选择创伤性脑损伤患者55例，按格拉斯哥昏迷评分（GCS）分轻中度组（9—15分，25例）和重度组（3—8分，30例）；选择30例正常体检者作为对照组。采集伤后12h静脉血，以ELISA法测定三组血清UCH—L1及NSE的含量，分析其与损伤程度及预后的关系。结果与对照组相比，轻中度、重度组患者伤后12h血清UCH—L1及NSE浓度升高（P〈0．05）；且重度组高于轻中度组（P〈0．05）。血清UCH-L1及NSE水平与创伤性脑损伤患者的预后呈负相关（r=-0．657，r=-0．728，P〈0．01）。结论创伤性脑损伤患者血清UCH-L1和NSE检测有助于判断损伤程度和预后。

英文摘要：

Objective To detect serum levels of ubiquitin carboxy-terminal hydrolase L1 （UCH-L1） and neuron specific enolase（NSE） and explore their clinical significance in the patients with traumatic brain injury（TBI）. Methods With ELISA, serum levels of UCH-L1 and NSE were detected in TBI patients with Glasgow Coma Scale（GCS） of 9-15（group A, 25 cases）, TBI patients with GCS score of 5-8（group B, 30 cases） at 12 h after TBI, and healthy persons（group C, 30 cases）. The correlation between serum levels of UCH-L1 and NSE with the prognosis of TBI cases was analyzed. Results Compared with group C,serum levels of UCH-L1 and NSE were higher in groups of A and B than those in group C（P〈0. 05）,which were higher in group B than those in group A （P〈0. 05）. Serum levels of UCH-L1 and NSE were negatively correlated with the prognosis of TBI patients（r=-0. 657, r=-0. 728,P〈0. 01）. Conclusion Detection of serum UCH-L1 and NSE is helpful in evaluating the severity of TBI and predicting early prognosis of the patients with TBI.